Second Annual INSPECTOR MR Spectroscopy Workshop: November 30, 2018

8:50 AM - 9:00 AM
Welcome
Christoph Juchem, Ph.D., Columbia University

9:00 AM - 9:30 AM
MR Spectroscopy of the Human Body
Martin Gajdosik, Ph.D., Columbia University

9:30 AM - 10:00 AM
An Introduction to J-Difference Editing and Application for Treatment Response Prediction in Major Depressive Disorder
Kenneth Wengler, Ph.D., Stony Brook University

10:00 AM - 10:30 PM
MRS biomarkers in traumatic brain injury (TBI)
Ivan Kirov, Ph.D., New York University

10:30 AM - 11:00 AM
Coffee Break - Meet and Greet

11:00 AM - 11:30 AM
¹³C Labeling Studies and Challenges of Spectral and Kinetic Fitting
Graeme Mason, Ph.D., Yale University

11:30 AM - 12:00 PM
Development of Radio-Frequency Pulses for MR Spectroscopy
Priti Balchandani, Ph.D., Mount Sinai School of Medicine

12:00 PM - 12:30 PM
Towards an Integrated Understanding of Neurotransmitter Dysfunction in Schizophrenia: A Multimodal MR Study
Jodi Weinstein, M.D., Stony Brook University

12:30 PM - 1:30 PM
Lunch

1:30 PM - 2:00 PM
Introduction to INSPECTOR Software
Overview, download, license, OS, installation, documentation, tooltips, protocol files, setup, usage, customization, support, user community
Christoph Juchem, Ph.D., Columbia University

2:00 PM - 2:45 PM
Data Handling and Quality Assessment
Supported data formats and experiments, receiver/repetition/scan handling, FID/spectrum visualization, Rx/NR selection, QA Tool, spectrum superposition/series/array, dummy scans, phase cycling, combination of Rx/NR, eddy current correction, automated frequency/phase/EC correction, data replacement.
Usage example: Short-Echo Time ¹H MRS of the human brain at 7T with STEAM
Christoph Juchem, Ph.D., Columbia University

2:45 PM - 3:00 PM
Break

3:00 PM - 3:45 PM
Data Processing and Corrections
Spectral post-processing, alignment of editing conditions, baseline correction, water removal, preparation for quantification.
Usage example: 1H JDE of glutathione (GSH) and GABA in human brain at 7T with MEGA sLASER
Kelley Swanberg, M.Sc. & Christoph Juchem, Ph.D., Columbia University

3:45 PM - 4:30 PM
LCM Basis and Quantification
Concept of LCM analysis, LCM parameters, baseline, CRLB/Hessian/Monte-Carlo for confidence analysis, independent/coupled CRLB, spectrum preparation, individual/linked fitting parameters.
Visualization, documentation, data/result export, automation.
Usage example: 1H JDE of glutathione (GSH) and GABA in human brain at 7T with MEGA sLASER
Kelley Swanberg, M.Sc. & Christoph Juchem, Ph.D., Columbia University

4:30 PM - 4:45 PM
Break

4:45 PM - 5:30 PM
Basis Set Creation and Handling
Density matrix simulations of magnetic resonance spectra
Usage example: 1H JDE of glutathione (GSH) and GABA in human brain at 7T with MEGA sLASER
Karl Landheer, Ph.D. & Christoph Juchem, Ph.D., Columbia University

5:30 PM - 5:40 PM
INSPECTOR as a Tool for Teaching
Data structures and handling, processing concepts, effects of apodization/zero-filling/line broadening etc, simulation of singlet array, synthesis of brain-like spectrum, addition of noise, impact of noise on quantification
Christoph Juchem, Ph.D., Columbia University

5:40 - 5:45 PM
Final Comments & Adjournment
Christoph Juchem, Ph.D., Columbia University

File Upload

INSPECTOR_2ndWorkshop2018_Schedule.pdf