First Annual INSPECTOR MR Spectroscopy Workshop
Columbia University in the City of New York
Radiology Department, 622 West 168 Street, New York, NY 10032
Friday, 12/08/2017, 9:00 am - 4:40 pm, conference room 303/304
9:00 AM - 9:10 AM
Welcome
Christoph Juchem, PhD
9:10 AM - 9:50 AM
Introduction to Magnetic Resonance Spectroscopy
Karl Landheer, PhD
9:50 AM - 10:30 AM
MRS of Neurotransmitters and Neuroenergetics
Douglas Rothman, PhD
10:30 AM - 10:45 AM
Break
10:45 AM - 11:25 PM
MRS of Psychiatric Disorders: Schizophrenia, OCD and Depression
Lawrence Kegeles, MD, PhD
11:25 AM - 12:05 PM
MRS of Multiple Sclerosis Pathology
Kelley Swanberg, MSc
12:15 PM - 1:45 PM
Lunch
1:45 PM - 2:15 PM
Introduction to the INSPECTOR Software
Overview, download, license, OS, installation, documentation, tooltips, protocol files, setup, usage, customization, support, user community
Christoph Juchem, PhD
2:15 PM - 2:45 PM
Data Handling and Quality Assessment
Supported data formats and experiments, receiver/repetition/scan handling, FID/spectrum visualization, Rx/NR selection, QA Tool, spectrum superposition/series/array, dummy scans, phase cycling, combination of Rx/NR
Usage example: 1H MRS of the human brain at 7T with sLASER
Christoph Juchem, PhD
2:45 PM - 3:15 PM
Data Processing and Corrections
Eddy current correction, automated frequency/phase/EC correction, data replacement, alignment of editing conditions, processing, baseline correction, water removal, preparation for quantification.
Usage example: 1H JDE of glutathione (GSH) and GABA in human brain at 7T with MEGA sLASER
Kelley Swanberg, MSc
3:15 PM - 3:30 PM
Break
3:30 PM - 4:00 PM
LCM Basis and Quantification
Concept of LCM analysis, spectrum preparation, basis set creation and handling, LCM parameters, individual/linked fitting parameters, baseline, CRLB/Hessian/Monte-Carlo for confidence analysis, independent/coupled CRLB, visualization, documentation, data/result export, automation.
Christoph Juchem, PhD
4:00 PM - 4:30 PM
INSPECTOR as a Tool for Teaching
Data structures and handling, processing concepts, effects of apodization/zero-filling/line broadening etc, simulation of singlet array, synthesis of brain-like spectrum, addition of noise, impact of noise on quantification
Christoph Juchem, PhD
4:30 - 4:40 PM
Final Comments & Adjournment
Christoph Juchem, PhD
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