Research Interests
in vivo proton magnetic resonance spectroscopy; in vivo proton relaxometry; spectroscopic metabolite quantification; central nervous remodeling post-brain injury and amputation; hippocampal electrophysiology; animal disease models; sleep and memory consolidation; mood disorders; addiction
Biography
Kelley Swanberg has over a decade of experience researching mammalian brain function at multiple levels of detail. In past work she has explored the pharmacological correlates of behavior in animal models of affective disorder, the modulation of spontaneous and evoked hippocampal electrophysiology by low-intensity ultrasound and pharmaceuticals like caffeine, the functional manifestations of neural plasticity following limb amputation, and the roles of sleep and affect in memory consolidation. She joined the MR-SCIENCE laboratory in 2015 and currently investigates the methodology and application of in vivo proton spectroscopy at 7 Tesla to the metabolic characterization of central nervous pathology, particularly in multiple sclerosis. Kelley’s work aims to marshal a broad range of experimental and observational data to construct predictive models that can enable practical advancements in treatments for neurological illness. Proficient in several languages, she has participated in collaborations spanning three continents and believes that the reasoned synthesis of widely opposing perspectives is the most efficient means to meaningful discovery.
Pronouns: she/they
Education & Training
PhD in Biomedical Engineering, Columbia University,
School of Engineering and Applied Science (2022)
MSc in Biomedical Engineering, Columbia University,
School of Engineering and Applied Science (2018)
MSc in Korean Medicine, Kyung Hee University
Graduate School of East-West Medical Science (2015)
BA in Neurobiology, magna cum laude and Phi Beta Kappa,
Harvard University (2009)
Honors & Recognition
Engineering Graduate Student Council Professional Development Scholarship
Columbia University Fu Foundation School of Engineering and Applied Science, New York, United States (2018, 2019)
Educational Stipend, International Society for Magnetic Resonance in Medicine Annual Meeting
International Society for Magnetic Resonance in Medicine (ISMRM) (2017, 2018, 2019)
Liu Ping Fellowship
Columbia University Fu Foundation School of Engineering and Applied Science, New York, United States (2017)
Most Outstanding Master's Thesis Award
Kyung Hee University Graduate School of East-West Medical Science, Seoul, Republic of Korea (2015)
1st Place Graduate Student and Postdoctoral Fellow Research Talk Award
12th Korea-Japan Joint Symposium on Brain, Cardiac, and Smooth Muscle Sciences, Seoul, Republic of Korea (2015)
Best Poster Award, Korean Society of Brain and Neural Science
3rd Congress of the Asian Society of Neuropathology, and Korean Society for Neurodegenerative Disease, Seoul, Republic of Korea (2015)
Select Publications
Swanberg KM, Kurada AV, Prinsen HP, and Juchem C. (2022). Multiple sclerosis diagnosis and phenotype identification by multivariate classification of in vivo frontal cortex metabolite profiles. Scientific Reports 12, 13888. https://doi.org/10.1038/s41598-022-17741-8
Swanberg KM, Prinsen H, DeStefano K, Bailey M, Kurada AV, Pitt D, Fulbright RK, and Juchem C. (2021). In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing-remitting multiple sclerosis. NMR in Biomedicine 34(11): e4590.
Gajdošík M, Landheer K, Swanberg KM, and Juchem C (2021). INSPECTOR: Free software for magnetic resonance spectroscopy data Inspection, processing, simulation and analysis. Scientific Reports 11, 2094. https://doi.org/10.1038/s41598-021-81193-9
Swanberg KM, Landheer K, Pitt D, and Juchem C. (2019). Quantifying the metabolic signature of multiple sclerosis by in vivo proton magnetic resonance spectroscopy: Current challenges and future outlook in the translation from proton signal to diagnostic biomarker. Frontiers in Neurology 2019; 10:1173.
Swanberg KM, Prinsen H, Coman D, de Graaf RA, Juchem C: Quantification of glutathione transverse relaxation time T2 using echo time extension with variable refocusing selectivity and symmetry in the human brain at 7 Tesla. J Magn Reson. 2018 May; 290:1-11. PMID: 29524756
Kim, H.B., K.M. Swanberg, H.S. Han, J.C. Kim, J.W. Kim, S.O. Lee, C.J. Lee, S.H. Maeng, T.S. Kim, J.H. Park. (2017). Prolonged stimulation with low-intensity ultrasound induces sustained increases in spontaneous hippocampal culture spiking activity. Journal of Neuroscience Research 95(3): 885-896.