Juchem Lab

Magnetic Resonance Engineering - from Bench to Bedside

Our laboratory pursues MR engineering in the fields of magnetic resonance imaging (MRI), spectroscopy (MRS) and spectroscopic imaging (MRSI) to advance their clinical potential for the study of neurodegenerative diseases. To this end, MR method developments are combined with state-of-the-art MRI, MRS and MRSI techniques to derive in vivo direct knowledge of the pathobiochemistry underlying clinical conditions such as multiple sclerosis, diabetes or post-traumatic stress disorder (PTSD). 

Detection sensitivity and spectral dispersion of MRS/MRSI are improved with the application of ultra-high scanner B0 fields. However, true benefits are only achieved if the concomitant methodological and technical challenges can be overcome. As such, our methodological work sets the stage for in vivo clinical research of the human brain.

Principal Investigator

Christoph Juchem, PhD

Associate Professor, Departments of Biomedical Engineering and Radiology

NIH Biosketch

 

Novel Application of Machine Learning to 1H-MRS Metabolomics of Multiple Sclerosis Phenotype Recently Published

Congratulations to authors postdoctoral research scientist Dr. Kelley Swanberg and laboratory alumni Mr. Abhinav Kurada and Dr. Hetty Prinsen on their publication entitled "Multiple sclerosis diagnosis and phenotype identification by multivariate classification of in vivo frontal cortex metabolite profiles." This work demonstrates the capacity of several supervised classification algorithms to distinguish between multiple sclerosis phenotypes on the basis of untransformed 1H-MRS-visible prefrontal cortex metabolite concentrations alone.

Juchem and Olive Laboratories Receive Prestigious 2022 Blavatnik Seed Grant to Elucidate Ferroptosis In Vivo

A new collaboration between the MR SCIENCE laboratory at SEAS and Dr. Ken Olive's lab at the Herbert Irving Comprehensive Cancer Center receives a 2022 HICCC-SEAS Joint Seed Grant for "Measuring ferroptosis in vivo using magnetic resonance spectroscopy" supported through the Blavatnik Fund for Innovation. 

Ph.D. student Ronald Instrella awarded 2nd place for best MRS poster at ISMRM, TL1 Fellowship

 

Congratulations to Mr. Ronald Instrella, who was awarded 2nd place during the MR Spectroscopy study group’s best poster contest at the 2022 Joint Annual Meeting SIMRM-ESMRMB in London, United Kingdom on 7-12 May 2022. His abstract, “Error Propagation in Absolute Metabolite Quantification for MR Spectroscopy of the Human Brain,” was selected as a finalist and subsequently awarded 2nd place after an oral presentation at the study group meeting.

Undergraduate Leonardo Campos Gives Talk on Magna Cum Laude Abstract at ISMRM Annual Meeting

Congratulations to Mr. Leonardo Campos, whose Magna Cum Laude award-winning abstract with MR SCIENCE Laboratory member Dr. Kelley Swanberg and alumni Dr. Martin Gajdošík and Dr. Karl Landheer was selected for presentation at the 2022 Joint Annual Meeting ISMRM-ESMRMB in London, United Kingdom on 7-12 May 2022.
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