Juchem Lab

Magnetic Resonance Engineering - from Bench to Bedside

Our laboratory pursues MR engineering in the fields of magnetic resonance imaging (MRI), spectroscopy (MRS) and spectroscopic imaging (MRSI) to advance their clinical potential for the study of neurodegenerative diseases. To this end, MR method developments are combined with state-of-the-art MRI, MRS and MRSI techniques to derive in vivo direct knowledge of the pathobiochemistry underlying clinical conditions such as multiple sclerosis, diabetes or post-traumatic stress disorder (PTSD). 

Detection sensitivity and spectral dispersion of MRS/MRSI are improved with the application of ultra-high scanner B0 fields. However, true benefits are only achieved if the concomitant methodological and technical challenges can be overcome. As such, our methodological work sets the stage for in vivo clinical research of the human brain.

Principal Investigator

Christoph Juchem, PhD

Associate Professor, Departments of Biomedical Engineering and Radiology

NIH Biosketch


7T MRS study of Progressive and Relapsing-remitting Multiple Sclerosis Featured as NMR in Biomedicine Cover Image

Team of researchers led by the Juchem lab discovers differential metabolic abnormalities in the prefrontal cortex of patients with multiple sclerosis using state-of-the-art magnetic resonance spectroscopy (MRS) at ultra-high 7T field (Cover image of NMR in Biomedicine!)

MR SCIENCE Laboratory Student and Alumni Work Selected for Presentation by New York Academy of Sciences

The New York Academy of Sciences recently selected the work of MR SCIENCE Laboratory student Kelley Swanberg with laboratory alumni Abhinav Kurada and Dr. Hetty Prinsen to be presented at an internationally broadcast webinar "Emerging Research & Trial Strategies for Progressive Multiple Sclerosis." 

MR SCIENCE Laboratory Welcomes Two Newest Members

Welcome to MR SCIENCE Laboratory postdoctoral associate Dr. Carlotta Ianniello, the newest member of the portable scanner multi-coil hardware and magnetic resonance imaging team, and Ph.D. graduate student Ron Instrella, the newest member of the in vivo magnetic resonance spectroscopy team. More details can be found here on the MR SCIENCE Laboratory People page. We look forward to witnessing your research in action!

MR SCIENCE Laboratory Associate Research Scientist Spotlighted During Postdoc Appreciation Week


In light of national postdoctoral appreciation week, Associate Research Scientist Dr. Sebastian Theilenberg was spotlighted by the Columbia University Office for Postdoctoral Affairs for the significant work he did in our lab this past year during the pandemic. Congratulations and thank you to Sebastian for his notable contributions to the MR SCIENCE Laboratory!


Fall 2021 Course Registration Open! Magnetic Resonance Spectroscopy: A Window to the Living Brain

Team-taught by experts from SEAS and CUMC in magnetic resonance and psychiatry, BMEN4490 covers all aspects of in vivo MRS from theory to experiment, including but not limited to study design and data acquisition in human patients through results quantification and ultimate clinical interpretation.
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