Juchem Lab

Magnetic Resonance Engineering - from Bench to Bedside

Our laboratory pursues MR engineering in the fields of magnetic resonance imaging (MRI), spectroscopy (MRS) and spectroscopic imaging (MRSI) to advance their clinical potential for the study of neurodegenerative diseases. To this end, MR method developments are combined with state-of-the-art MRI, MRS and MRSI techniques to derive in vivo direct knowledge of the pathobiochemistry underlying clinical conditions such as multiple sclerosis, diabetes or post-traumatic stress disorder (PTSD). 

Detection sensitivity and spectral dispersion of MRS/MRSI are improved with the application of ultra-high scanner B0 fields. However, true benefits are only achieved if the concomitant methodological and technical challenges can be overcome. As such, our methodological work sets the stage for in vivo clinical research of the human brain.

Principal Investigator

Christoph Juchem

Christoph Juchem, PhD

Associate Professor, Departments of Biomedical Engineering and Radiology

Novel Gradient Crusher Optimization Scheme Published in MRM

The MR SCIENCE lab has published a novel algorithm, referred to as Dephasing Optimization Through Coherence Order Pathway Selection (DOTCOPS), which designs crusher schemes for any magnetic resonance spectroscopy experiment, and can be used for any metabolite of interest. DOTCOPS uses a numerical optimization to provide maximum crushing to all unwanted coherence pathways, thereby eliminating the effects of spurious echoes which can contaminate the spectrum or cause voxel mislocalization.

First Human Brain JD-Edited GSH T2 Value at 7 T Published in JMR

The MR SCIENCE lab has published the first in vivo quantification of transverse relaxation rate T2 for edited glutathione at 7 Tesla. Performed in the human occipital cortex, their method used can be generally applied to calculate the T2 of any measurable metabolite, at great benefit to the investigation of those that exhibit J-evolution from strong coupling. Second-year Biomedical Engineering Ph.D. student Ms. Kelley Swanberg has first-authored the publication, which is currently in press at the Journal of Magnetic Resonance:

MR SCIENCE Lab Members Receive 2018 GEM-ASEE NSF/Sloan Foundation Travel Fellowships

 

 

Postdoctoral fellow Dr. Karl Landheer and second-year Biomedical Engineering Ph.D. student Ms. Kelley Swanberg receive scholarships to present their work at the GEM-ASEE Doctoral Research Showcase, funded by the National Science Foundation and Alfred P. Sloan Foundation, at the Mayflower Hotel in Washington, D.C. in January 2018.

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